Botulax is made in Korea by Hugel Pharma. The advantages of Botulax is that Botulax is strictly controlled for safety and high stable potency, has purity of 99% and safety & efficacy have been successfully proved compared with Botox. Botulax contains 100 units (U) of Clostridium botulinum toxin type A, 0.5 milligrams of albumin (human)and 0.9 milligrams of sodium chloride in a sterile, vacuum-dried from without a preservative. Botulax is approved in Thailand and South America, however you need to check your own country import policy, botulax is waitting for FDA approval in the USA, it is in clinical trail process.
It appears as a lyophilized white powder for injection in a colorless transparent vial.
Expire date will be 36 months from the manufacture date.
The unopened lyophilized vial should be stored in a freezer (below -5 degree) or refrigerator (2-8 degree)
Characteristics of Botulax:
Higher specific activity than those of other company’s botolinum toxin products by improving lyophilization process
Botulinum toxin type A neutroxin: purified from Clostridium botulinum type A
Albumin: Human serum albumin,bulking and stabilizing agent and adhesion reducer.
KP grade NaCl: Bulking agent and keeping isotonicity during formulation
KP grade Developmental status:
2007.5: reported nonclinical study
2008.3: reported clinically study Phase l
2009.7: Finished Phase lll clinically study
Facility: GMP approved by KFDA
Features of Botulax Botulium Toxin Type A
Excellent Effect – Result appeciable improvement
Simple Procedure – Just by few tiny injections
Short Treatment – 10 minutes, as short as a tea break
No Down Time – Resume normal work right away
Fast Onset- Take only 2 to 3 days to see noticeable effect
Outstanding Efficacy – Over 98% users satisfied with the Botulax® treatments
Proven efficacy & Safety – The efficacy and safety of Botulium Toxin Type A are proved and verified to be comparable to botox in clinical studies.
Global Product – Global Product, Botulium Toxin Type A has been sold in over 25 countries.
Guarateed Safety – Approved by Health Authorities with over 10 years’ clinical practices.
Not just cosmetic Botox, Botulium Toxin Type A also has therapeutic applications, Botulium Toxin Type A is used for the treatment of benign essential blepharspasm in patients 18 years of age and above. For the treatment of equinus foot deformity due to spasticity in pediatric cerebral palsy patients 2 years of age and above. And as many know Botox, for temporary improvement of serious glabellar wrinkles ranging from moderate to severe associated with corrugators muscle and/or procerus muscle activities in adults over the age of 18 and below the age of 65. The vials are generally stored in a freezer or refrigerator and they retain a shelf life of 24 months.
For blepharospasm the initial recommended dose is 1.25 – 2.5 U (0.05 mL to 0.1 mL volume at each site) injected into the medial and lateral pre-tarsal orbicularis oculi of the upper lid and into the lateral pre-tarsal orbicularis oculi of the lower lid. For pediatric cerebral palsy, a total dose of 4U/kg bodyweight is recommended for the affected gastrocnemius muscle in patients with hemiplegia. And in patients with diplegia, the recommended dose is 6U/kg bodyweight divided between both legs. The maximum dose administered must not exceed 200U/patient at a time. For Glabellar wrinkles reconstituted sterile saline. 20U is used and there are additional application instructions for best practice, actual amounts vary on the presentation of the client.
In Blepharospasm, the effects should appear within three days and peak after three weeks. For pediatric cerebral palsy applications, the expectation is improvement within four weeks of the injection. The effects vary for glabellar wrinkles due to the usually individualized dosages.
There is the possibility of reactions at the site of an injection, and effects beyond the injection site, including but not limited to asthenia, generalized muscle weakness, diplopia, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence and breathing difficulties. Serious hypersensitivity has been reported as rare. There is a caution for people with pre-existing neuromuscular disorders, and for those with corneal exposure and ulceration in blepharospasm. Botulium Toxin Type A is not to be administered at all if a patient has a known allergy to any of the ingredients, or if the patients have neuromuscular junctional disorders or known to have adverse reactions. They should not be administered while taking muscle relaxants and some antibiotics. Further, the actual effects of prolonged use are not entirely explored. There is also additional advice for the specific therapeutic conditions mentioned, as this description is not comprehensive.
In the case of overdose
In the case of an overdose it has been advised that effects may not be immediate. It is further advised that the patient be monitored for muscle weakness and/or paralysis for a period of weeks after the occurrence. There is an anti-toxin available but the caution with the anti-toxin is that it will not reduce any already apparent effects.
Botulax 200U is a new generation of Botulinum Toxin Type A product with high purity and better effect. Botulax is develop over dozen purification processes such as sterilization, impurity removal, nucleic acid removal, heat removal, enzymatic hydrolysis, isoelectric point, salting out, dialysis, ultrafiltration, column chromatography, repeated recrystallization, etc. A single pure effective protein, without any impurities, so the product is high in purity, easy to dissolve, and the solution is clear and transparent after dissolution. Botulax is strictly certified by Korean KDA and GMP.
Botulax is uniquely formulated with good product stability. The biological wrinkle protectant, stabilizer and other auxiliary materials are unique, and have a good protective effect on the product. After the control experiment, the stability of Botulax is the best among the similar products in the world, and even it is placed at room temperature for over one week, the activity is basically not falling.
Botulax are safe and do not produce allergic reactions. There is no risk of viruses in blood products, and there is no disadvantage that macromolecular animal proteins are prone to allergic reactions. In addition, it is easily absorbed by the muscles and has a good nutritional effect on the injection site.
Ingredient: Clostridium Botulinum Toxin Type A (Strain: Clostridium botulinum CBFC26)
Storage instructions -
Keep sealed and store at 2~8°C
Expiry date -
36 months from the date of manufacture
A white injectable dry powder in a transparent glass vial which should become a colorless, transparent liquid when reconstituted with a solvent (normal saline solution)
1. Treatment of benign essential blepharospasm in adults over 18 years of age
2. Temporary improvement of moderate to severe glabellar lines that form as a result of corrugator muscles and/or procerus muscle activity in adults aged between 18 and 65
3. Treatment of post-stroke upper-limb spasticity
4. Treatment for pediatric cerebral palsy patient aged 2 or above with dynamic equinus foot deformity by spasticity
Botulinum Toxin Type A blocks signals from the nerves to the muscles. The injected muscle can no longer contract, which causes the wrinkles to relax and soften. It is most often used on forehead lines, crow’s feet (lines around the eye) and frown lines.
Botulax contains 50 units (U) of Clostridium botulinum toxin type A, 0.5 milligrams of albumin (human)and 0.9 milligrams of sodium chloride in a sterile, vacuum-dried from without a preservative. Botulinum toxin type A neutroxin: purified from Clostridium botulinum type A Albumin: Human serum albumin,bulking and stabilizing agent and adhesion reducer.
Botulax has been successfully used for hydrosis, the injection procedure in the presence of a problem of hyperhidrosis (increased sweating) gives a stable, long-lasting effect.
Type A botulinum toxin - hemagglutinin complex - a highly purified neurotoxic protein produced in compliance with local and international GMP standards adopted worldwide.
Dosage form: Lyophilisate for the preparation of a solution for intramuscular administration.
Size of toxin complex is 900kDa, minimize spread of botulinum toxin outside of the injection site.
Such large and homogeneous size of the toxin complex ensures precise and uniform effect at the time of injection, guaranteeing high patient satisfaction with Botulax.
1. Benign essential blepharospasm in adult patients, 18 years age or above
2. Temporary improvement of serious glabellar wrinkles ranging from moderate to severe associated with corrugators muscle and/or procerus muscle activities in adults aged between 18 and 65
Prescription Botulax 50
The drug is used in the forehead, interbrow zone, nose bridge. Correction results in the eyes, nasolabial folds, chin area and corners of the mouth. It is also effective for the correction of facial contours (Botox lifting), as a result, the restoration of the lost shape of the facial contours, skin tightening is achieved.
a history of hypersensitivity to any component of the drug;
inflammatory process at the site of the alleged injection (s);
acute phase of infectious diseases;
myasthenia gravis or Liabert-Eaton syndrome;
Hutox is a Botulinum Toxin Type A-based injectable product that is valued in the medical and the beauty fields. With its highly purified composition and one-of-a-kind formula, it is equally good at correcting signs of aging and treating a long list of clinical conditions related to muscle spasticity, for example. It has qualities similar to those of Botox and it can be injected into the patient’s face or body. With it, adult patients can say goodbye to medium lines and even to severe facial wrinkles. That incredible result is achieved by the natural properties of this injectable which has the power to prevent the contraction of those muscles that have been injected with it. The treatment itself is very localized which means that it focuses only on problem areas that show the above-mentioned signs of aging. As a result, patients need to only undergo a quick injection procedure that is 10-20-minutes long. Downtime is minimal.
Among the top advantages of using this Botox-like neurotoxic product is its incredibly high level of purity (about 99%). This makes Hutox much stronger and more effective compared to its rivals. That is why it manages to deliver high patient satisfaction. To achieve this amazing product purity, Huons has relied on a new-generation production technology.
Hutox can be used for the treatment of medical conditions such as lower or upper limb muscle spasticity or even on patients who have equinus foot deformity. The treatment process and the longevity of effects are similar to those observed after a cosmetic rejuvenation procedure with this innovative product.
- Painless even when used without aenesthetic
- Effects visible after one administration, starting from 2 weeks after injection, and peaks around 3~4 weeks.
- Effects last for 6~12 months (4~6 months for other products)
- Must be kept refrigerated
Innotox 50 units is an innovative botulinum toxin type developed by the South Korean company Medytox Inc.
This drug has gained great popularity in clinics of South Korea and Japan due to several advantages:
• Product structure: Innotox is available in a new liquid phase, so it does not require dilution. One bottle contains a ready-made product solution for 50 units.
• Temperature: insensitive to temperature extremes, in contrast to solid-phase preparations. However, it is recommended that you keep it in the refrigerator until use. The opened bottle can be stored in the refrigerator at a temperature of 2 to 8 degrees 72 hours.
• Diffusion: has the least diffusion among all botulinum toxins currently known.
• Effect: during the course of procedures, the effect lasts up to 8 months, in contrast to other botulinum toxins, in which the effect lasts up to 4 months.
Innotox 50U is designed to eliminate wrinkles associated with muscle spasticity or active facial expressions. Eliminates lines and folds in the eye area, interbrow zone, forehead, around the mouth.
• Eliminate wrinkles associated with muscle spasticity or active facial expressions.
• Eliminates lines and folds in the eye area, eyebrow area, forehead, around the mouth.
• Age before 18 and after 65 years.
• Hypersensitivity to the components of the composition.
• Pregnancy and lactation.
• Inflammatory processes on the skin in the target area.
• Blood coagulation disorders.
• Oncological diseases.
• Pronounced hernial protrusions on the lower and upper eyelids.
Composition of the product:
Composition: the improved formula of the drug does not contain: proteins, albumin, gelatin, compared with other similar drugs.
• Botulinum toxin type A.
• Polysorbate 20.
• Buffered saline phosphate pH 7.0.
Type of packaging: box with a vial
Volume: 50 units
Expiration date: 3 years from the date of production
Storage conditions: Store at a temperature of 2 C to 8 C
Neuronox is a product similar to Botox, a Botulinum toxin type A based product, which is derived and purified from Clostridium botulinum. The main function of botulinum based products is to be injected into muscles and block their ability to contract. The application of such products is both medical and cosmetic, as they have been known to successfully treat conditions like migraine. However, they are most popular as a powerful means for cosmetic corrections and anti-age product.
Neuronox is injected into the patients muscles in order to locally reduce muscle activity. The practical effect of injecting the botulinum product is inhibiting the release of acetylcholine.
As a means for treating medical conditions, Neuronox has been successfully applied to patients suffering from hemifascial spasm, blepharospam and cervical dystonia. But it is also very potent in shaping facial lines, hiding wrinkles and other signs of aging.